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Ex vivo perfusion of human lymph nodes †
Author(s) -
Xu Qian,
Moore James E
Publication year - 2020
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.5454
Subject(s) - ex vivo , lymphatic system , lymph , perfusion , breast cancer , immune system , axillary lymph nodes , medicine , pathology , cancer , in vivo , pathological , immunology , biology , microbiology and biotechnology
In a recent study published in The Journal of Pathology , Barrow‐McGee et al described a feasibility study of a real‐time ex vivo perfusion model of the axillary lymph nodes (ALNs) from breast cancer patients for immune‐oncological investigations. The study showed that perfused ALNs remain viable for up to 24 h, and perfusion of therapeutic antibodies confirmed the ability to reach ALN‐resident cells. This work is a highly encouraging demonstration of feasibility for further research into lymphatic system function, with applications to immune function, vaccinations, and cancer. © 2020 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.