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Distinct mutational landscape of inverted urothelial papilloma
Author(s) -
Akgul Mahmut,
MacLennan Gregory T,
Cheng Liang
Publication year - 2019
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.5307
Subject(s) - hras , gene , context (archaeology) , urothelial carcinoma , cancer research , biology , mapk/erk pathway , inverted papilloma , mutation , carcinoma , neuroblastoma ras viral oncogene homolog , pathological , medicine , papilloma , cancer , genetics , bladder cancer , pathology , signal transduction , paleontology , kras
A recent study has identified gene mutations involving the MAPK/ERK pathway, particularly the HRAS gene, in all inverted urothelial papillomas (IUPs), in the absence of pathway mutations in TERT promoter, FGFR3 , and TP53 / RB1 genes. Neither recurrence nor progression was observed in IUPs. These data support several longstanding hypotheses: (1) IUPs are benign and do not recur or progress; (2) they harbor mutations that are different from those of urothelial carcinoma; and (3) they arise through different molecular mechanisms than low‐ or high‐grade urothelial carcinoma. As the most critical differential diagnosis in this context is inverted‐type urothelial carcinoma, more comprehensive studies are needed to compare and contrast these entities. © 2019 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.