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Disease‐biased and shared characteristics of the immunoglobulin gene repertoires in marginal zone B cell lymphoproliferations
Author(s) -
Xochelli Aliki,
Bikos Vasilis,
Polychronidou Eleftheria,
Galigalidou Chrysi,
Agathangelidis Andreas,
Charlotte Frédéric,
Moschonas Panagiotis,
Davis Zadie,
Colombo Monica,
Roumelioti Maria,
Sutton LesleyAnn,
Groenen Patricia,
van den Brand Michiel,
Boudjoghra Myriam,
Algara Patricia,
TraverseGlehen Alexandra,
Ferrer Ana,
Stalika Evangelia,
Karypidou Maria,
Kanellis George,
Kalpadakis Christina,
Mollejo Manuella,
Pangalis Gerasimos,
Vlamos Panayiotis,
Amini RoseMarie,
Pospisilova Sarka,
Gonzalez David,
Ponzoni Maurilio,
Anagnostopoulos Achilles,
Giudicelli Véronique,
Lefranc MariePaule,
Espinet Blanca,
Panagiotidis Panagiotis,
Piris Miguel Angel,
Du MingQing,
Rosenquist Richard,
Papadaki Theodora,
Belessi Chrysoula,
Ferrarini Manlio,
Oscier David,
Tzovaras Dimitrios,
Ghia Paolo,
Davi Frederic,
Hadzidimitriou Anastasia,
Stamatopoulos Kostas
Publication year - 2019
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.5209
Subject(s) - marginal zone , biology , antibody , immunology , b cell , splenic marginal zone lymphoma , gene , chronic lymphocytic leukemia , pathological , leukemia , pathology , genetics , medicine
The B cell receptor immunoglobulin (Ig) gene repertoires of marginal zone (MZ) lymphoproliferations were analyzed in order to obtain insight into their ontogenetic relationships. Our cohort included cases with MZ lymphomas ( n = 488), i.e. splenic (SMZL), nodal (NMZL) and extranodal (ENMZL), as well as provisional entities ( n = 76), according to the WHO classification. The most striking Ig gene repertoire skewing was observed in SMZL. However, restrictions were also identified in all other MZ lymphomas studied, particularly ENMZL, with significantly different Ig gene distributions depending on the primary site of involvement. Cross‐entity comparisons of the MZ Ig sequence dataset with a large dataset of Ig sequences (MZ‐related or not; n = 65 837) revealed four major clusters of cases sharing homologous (‘public’) heavy variable complementarity‐determining region 3. These clusters included rearrangements from SMZL, ENMZL (gastric, salivary gland, ocular adnexa), chronic lymphocytic leukemia, but also rheumatoid factors and non‐malignant splenic MZ cells. In conclusion, different MZ lymphomas display biased immunogenetic signatures indicating distinct antigen exposure histories. The existence of rare public stereotypes raises the intriguing possibility that common, pathogen‐triggered, immune‐mediated mechanisms may result in diverse B lymphoproliferations due to targeting versatile progenitor B cells and/or operating in particular microenvironments. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.