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Bridging the molecular divide: alcohol‐induced downregulation of PAX9 and tumour development
Author(s) -
Fujihara Kenji Mark,
Clemons Nicholas James
Publication year - 2018
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.5041
Subject(s) - downregulation and upregulation , regulator , pathogenesis , carcinogen , cancer research , pathological , alcohol consumption , basal cell , biology , cell growth , alcohol , microbiology and biotechnology , gene , medicine , genetics , immunology , biochemistry
The pathogenesis of oro‐oesophaeal squamous cell carcinoma is causally linked to the consumption of alcohol. Beyond the carcinogenic effects of ethanol and its metabolites via DNA damage, the precise mechanisms by which alcohol drives tumourigenesis remain to be fully elucidated. A novel contributor now revealed is aberrant differentiation and proliferation mediated by suppression of PAX9, a key regulator of normal squamous maturation in oro‐oesophageal tissues. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.