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Ultraviolet light and melanoma
Author(s) -
Craig Sarah,
Earnshaw Charles H,
Virós Amaya
Publication year - 2018
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.5039
Subject(s) - melanoma , ultraviolet radiation , biology , disease , pathological , ultraviolet light , genetics , genome , dna sequencing , computational biology , medicine , dna , gene , pathology , chemistry , photochemistry , radiochemistry
Melanoma is a clinically heterogeneous disease, and current strategies for treatment of the primary tumour are based on pathological criteria alone. In the recent past, several DNA‐sequencing and RNA‐sequencing studies of primary and advanced melanoma samples have identified unique relationships between somatic mutations, genomic aberrations, and the genetic fingerprint of ultraviolet radiation (UVR). The recurrent patterns of genomic alterations reveal different disease pathways, drug targets and mechanisms limiting drug response. Here, we examine the known associations between the molecular categories of melanoma and the multidimensional UVR damage. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.