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Role of Wnt signalling in advanced prostate cancer
Author(s) -
Ahmad Imran,
Sansom Owen J
Publication year - 2018
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.5029
Subject(s) - prostate cancer , androgen receptor , wnt signaling pathway , mtorc1 , signalling , prostate , cancer research , pi3k/akt/mtor pathway , mapk/erk pathway , blockade , cancer , medicine , signalling pathways , receptor , computational biology , signal transduction , biology , microbiology and biotechnology
Recent next‐generation sequencing studies demonstrate that multiple pathways are often deregulated in advanced and metastatic prostate cancer (PC). In a recent issue of The Journal of Pathology , an elegant study by Jefferies et al used in vivo modelling to demonstrate how activation of the PI3K, WNT, and MAPK pathway converges on mTORC1 signalling to drive aggressive disease. The study also highlights that approaches to target advanced PC require intelligent combination of agents to target single/multiple signalling pathways in combination with androgen receptor (AR) blockade. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.