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Loss of the tumour suppressor gene AIP mediates the browning of human brown fat tumours
Author(s) -
Magnusson Linda,
Hansen Nils,
Saba Karim H,
Nilsson Jenny,
Fioretos Thoas,
Rissler Pehr,
Nord Karolin H
Publication year - 2017
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.4945
Subject(s) - phenotype , biology , tumor suppressor gene , gene silencing , browning , endocrinology , medicine , cancer research , gene , genetics , carcinogenesis , horticulture
Human brown fat tumours (hibernomas) show concomitant loss of the tumour suppressor genes MEN1 and AIP . We hypothesized that the brown fat phenotype is attributable to these mutations. Accordingly, in this study, we demonstrate that silencing of AIP in human brown preadipocytic and white fat cell lines results in the induction of the brown fat marker UCP1 . In human adipocytic tumours, loss of MEN1 was found both in white (one of 51 lipomas) and in brown fat tumours. In contrast, concurrent loss of AIP was always accompanied by a brown fat morphology. We conclude that this white‐to‐brown phenotype switch in brown fat tumours is mediated by the loss of AIP . Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.