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Genomic signatures of pancreatic adenosquamous carcinoma (PASC)
Author(s) -
Fang Yuan,
Su Zhe,
Xie Jing,
Xue Ruidong,
Ma Qi,
Li Yanmeng,
Zhao Yifan,
Song Zeshi,
Lu Xiongxiong,
Li Hongwei,
Peng Chenghong,
Bai Fan,
Shen Baiyong
Publication year - 2017
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.4943
Subject(s) - pancreatic cancer , adenosquamous carcinoma , adenocarcinoma , pancreas , pancreatic ductal adenocarcinoma , pancreatic carcinoma , cancer , biology , cancer research , carcinoma , pathology , medicine
In pancreatic cancer, pancreatic adenosquamous carcinoma (PASC) containing both ductal adenocarcinoma and squamous carcinoma in the same tumour represents ∼4% of the total incidence. To date, the genomic features of this mixed tumour are still unknown. We analysed the genomes of 17 PASCs and 34 pancreatic ductal adenocarcinomas (PDACs), and showed that PASC carried highly enriched TP53 mutations and 3p loss as compared with PDAC. We also showed that adenomatous and squamous components of PASC harboured comparable genomic alterations, suggesting that the two cellular components develop from the same progenitor cancer cells. Our study has updated genomic knowledge to help with understanding mixed cancers of the pancreas. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.