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Angioimmunoblastic T‐cell lymphoma: more than a disease of T follicular helper cells
Author(s) -
Lemonnier François,
Mak Tak W
Publication year - 2017
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.4920
Subject(s) - angioimmunoblastic t cell lymphoma , lymphoma , cd20 , cancer research , biology , pathology , follicular dendritic cells , mutation , haematopoiesis , t cell , immunology , medicine , stem cell , antigen presenting cell , genetics , immune system , gene
Angioimmunoblastic T‐cell lymphoma ( AITL ) is one of the most frequent entities of peripheral T‐cell lymphoma. An AITL has two components: the AITL tumour cells, which have a T follicular helper ( TFH ) cell phenotype, and a surrounding and extensive tumour microenvironment that is populated with various reactive cell types, including B cells. Recurrent TET2 mutations have been described in 50–80% of AITLs , possibly occurring in a haematopoietic progenitor cell. An article published recently in the Journal of Pathology describes the use of microdissection to isolate PD1 + AITL tumour cells and CD20 + B cells from the AITL microenvironment, and to show that TET2 mutations are actually more frequent in these diseases than previously thought. Whereas TET2 mutations were detected in only six of 13 AITLs , 12 of 13 samples of microdissected PD1 + AITL tumour cells possessed this mutation. Moreover, TET2 mutations were detected in CD20 + B cells from the AITL microenvironment in six of nine informative cases. These results confirm that TET2 mutation is an early event in the majority of AITL cases, and that the driving molecular anomalies are not restricted to the T lineage tumour cells. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.