Premium
Multiple roles for TGFβ receptor type II in regulating the pancreatic response in acute pancreatitis
Author(s) -
Gittes George K
Publication year - 2016
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.4676
Subject(s) - acute pancreatitis , pancreatitis , confusion , pancreas , pathological , genetically modified mouse , inflammation , receptor , medicine , pancreatic cancer , endocrinology , pathology , transgene , biology , psychology , cancer , gene , psychoanalysis , biochemistry
In their recent publication in Journal of Pathology , Grabliauskaite and Sapanora and their colleagues in Zurich use a conditional ablation of the TGFβ type II receptor ( TBRII ) to analyse its specific role in pancreatic epithelial cells in response to a caerulein‐induced model of acute pancreatitis. These experiments help to clarify some confusion that has existed in the literature stemming from the use of a dominant‐negative transgenic TBRII mouse. The results point to a central role for TBRII in acinar cells in mitigating the overall response of the pancreas to the damage and inflammation of acute pancreatitis. Copyright © 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.