Multiple roles for TGFβ receptor type II in regulating the pancreatic response in acute pancreatitis | Zendy

Gittes George K | Zendy

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Multiple roles for TGFβ receptor type II in regulating the pancreatic response in acute pancreatitis

Author(s) -

Gittes George K

Publication year - 2016

Publication title -

the journal of pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.964

H-Index - 184

eISSN - 1096-9896

pISSN - 0022-3417

DOI - 10.1002/path.4676

Subject(s) - acute pancreatitis , pancreatitis , confusion , pancreas , pathological , genetically modified mouse , inflammation , receptor , medicine , pancreatic cancer , endocrinology , pathology , transgene , biology , psychology , cancer , gene , psychoanalysis , biochemistry

In their recent publication in Journal of Pathology , Grabliauskaite and Sapanora and their colleagues in Zurich use a conditional ablation of the TGFβ type II receptor ( TBRII ) to analyse its specific role in pancreatic epithelial cells in response to a caerulein‐induced model of acute pancreatitis. These experiments help to clarify some confusion that has existed in the literature stemming from the use of a dominant‐negative transgenic TBRII mouse. The results point to a central role for TBRII in acinar cells in mitigating the overall response of the pancreas to the damage and inflammation of acute pancreatitis. Copyright © 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

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