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The role of Kaposi sarcoma‐associated herpesvirus in the pathogenesis of Kaposi sarcoma
Author(s) -
Gramolelli Silvia,
Schulz Thomas F
Publication year - 2015
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.4441
Subject(s) - sarcoma , kaposi's sarcoma associated herpesvirus , pathogenesis , angiogenesis , kaposi's sarcoma , pathological , biology , pathology , viral oncogene , virus , virology , human herpesvirus , gammaherpesvirinae , immunology , herpesviridae , medicine , cancer research , cancer , viral disease , genetics
Abstract Kaposi sarcoma ( KS ) is an unusual vascular tumour caused by an oncogenic‐herpesvirus, Kaposi sarcoma‐associated herpesvirus ( KSHV ), also known as human herpesvirus 8 ( HHV 8). KS lesions are characterized by an abundant inflammatory infiltrate, the presence of KSHV ‐infected endothelial cells that show signs of aberrant differentiation, as well as faulty angiogenesis/ vascularization. Here we discuss the molecular mechanisms that lead to the development of these histological features of KS , with an emphasis on the viral proteins that are responsible for their development. Copyright © 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.