The role of Kaposi sarcoma‐associated herpesvirus in the pathogenesis of Kaposi sarcoma | Zendy

Gramolelli Silvia | Zendy; Schulz Thomas F | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

The role of Kaposi sarcoma‐associated herpesvirus in the pathogenesis of Kaposi sarcoma

Author(s) -

Gramolelli Silvia,

Schulz Thomas F

Publication year - 2015

Publication title -

the journal of pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.964

H-Index - 184

eISSN - 1096-9896

pISSN - 0022-3417

DOI - 10.1002/path.4441

Subject(s) - sarcoma , pathogenesis , kaposi's sarcoma , virology , medicine , human herpesvirus , pathology

Kaposi sarcoma ( KS ) is an unusual vascular tumour caused by an oncogenic‐herpesvirus, Kaposi sarcoma‐associated herpesvirus ( KSHV ), also known as human herpesvirus 8 ( HHV 8). KS lesions are characterized by an abundant inflammatory infiltrate, the presence of KSHV ‐infected endothelial cells that show signs of aberrant differentiation, as well as faulty angiogenesis/ vascularization. Here we discuss the molecular mechanisms that lead to the development of these histological features of KS , with an emphasis on the viral proteins that are responsible for their development. Copyright © 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research