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Mechanisms of age‐related macular degeneration and therapeutic opportunities
Author(s) -
van Lookeren Campagne Menno,
LeCouter Jennifer,
Yaspan Brian L,
Ye Weilan
Publication year - 2014
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.4266
Subject(s) - macular degeneration , blindness , medicine , socioeconomic status , pathological , degeneration (medical) , population , gerontology , optometry , pathology , ophthalmology , environmental health
As the age of the population increases in many nations, age‐related degenerative diseases pose significant socioeconomic challenges. One of the key degenerative diseases that compromise quality of life is age‐related macular degeneration ( AMD ). AMD is a multi‐faceted condition that affects the central retina, which ultimately leads to blindness in millions of people worldwide. The pathophysiology and risk factors for AMD are complex, and the symptoms manifest in multiple related but distinct forms. The ability to develop effective treatments for AMD will depend on a thorough understanding of the underlying pathophysiology, risk factors, and driver molecular pathways, as well as the ability to develop useful animal models. This review provides an overview of the aforementioned aspects in AMD . Copyright © 2013 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.