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E2F1 in renal cancer: Mr Hyde disguised as Dr Jekyll?
Author(s) -
Tian Weihua,
Cui Fenggong,
Esteban Miguel A
Publication year - 2013
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.4238
Subject(s) - e2f1 , context (archaeology) , renal cell carcinoma , cancer research , malignancy , cancer , kidney cancer , medicine , cell , suppressor , biology , oncology , cell cycle , genetics , paleontology
The transcription factor E2F1 has both oncogenic and tumour suppressor properties, depending on the context. Clarifying the function of E2F1 in different types of cancer is relevant because in those situations in which it acts as an oncogene there may be a route for therapeutic interference. Renal cell carcinoma is the most frequent form of kidney cancer in adults and inactivation of the von Hippel–Lindau ( VHL ) gene underlies most cases. This malignancy represents a challenge for standard therapies due to drug‐ and radio‐resistance, effects that fit well within the scope of functions of E2F1 . A new report by Mans et al postulates that up‐regulation of E2F1 in VHL ‐defective renal cell carcinoma induces cell senescence and can thus be considered a good prognostic factor. Here we discuss these findings in a wider context and propose that E2F1 may actually not play a uniform role in renal cell carcinoma but rather an ambiguous one whose deeper understanding could have practical implications. Copyright © 2013 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.