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The downside of ‘inappropriate messaging’: new insight into the development of testicular germ cell tumours in young men?
Author(s) -
Sharpe Richard M,
Mitchell Rod T
Publication year - 2013
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.4167
Subject(s) - mitosis , meiosis , germ cell , biology , germ , cancer research , disorders of sex development , carcinoma in situ , cell , testicular germ cell tumor , genetics , microbiology and biotechnology , carcinoma , testicular cancer , gene , cancer
How invasive testicular germ cell tumours ( TGCTs ) develop from precursor carcinoma in situ /intratubular germ cell neoplasia unclassified ( CIS / IGCNU ) cells, and only after puberty, is unknown. In the current issue of The Journal of Pathology , Jørgensen and colleagues have compared the protein expression profile of CIS before and after puberty and in pre‐invasive versus invasive TGCT and show that the mitosis–meiosis controller DMRT1 switches off in CIS cells postpubertally and is associated with invasiveness. They also show that CIS cells express a ‘confusing’ mix of pro‐ and anti‐meiotic proteins; this may predispose CIS cells to accumulate extra chromosomal material which ultimately leads to tumourigenesis.