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Inflammation, wound repair, and fibrosis: reassessing the spectrum of tissue injury and resolution
Author(s) -
White Eric S,
Mantovani Alberto R
Publication year - 2013
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.4126
Subject(s) - fibrosis , inflammation , medicine , tissue repair , wound healing , disease , pathological , intensive care medicine , population , bioinformatics , broad spectrum , collateral damage , pathology , immunology , biology , psychology , chemistry , environmental health , biomedical engineering , combinatorial chemistry , criminology
Estimates from various disease‐specific registries suggest that chronic inflammatory and fibrotic disorders affect a large proportion of the world's population, yet therapies for these conditions are largely ineffective. Recent advances in our collective understanding of mechanisms underlying both physiological and pathological repair of tissue injury are informing new clinical approaches to deal with various human inflammatory and fibrotic diseases. This 2013 Annual Review Issue of The Journal of Pathology offers an up‐to‐date glimpse of ongoing research in the fields of inflammation, wound healing, and tissue fibrosis, and highlights novel pathways and mechanisms that may be exploited to provide newer, more effective treatments to patients worldwide suffering from these conditions.