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From sentinel cells to inflammatory culprits: cancer‐associated fibroblasts in tumour‐related inflammation
Author(s) -
Servais Charlotte,
Erez Neta
Publication year - 2013
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.4103
Subject(s) - inflammation , crosstalk , metastasis , cancer associated fibroblasts , tumor microenvironment , cancer research , cancer cell , cancer , medicine , biology , immunology , tumor cells , physics , optics
Inflammation is now established as a hallmark of cancer. Cancer‐associated fibroblasts ( CAFs ) have been established as a key component of the crosstalk between tumour cells and their microenvironment. Central to the role of CAFs in facilitating tumour growth, invasion, and metastasis is their ability to orchestrate tumour‐related inflammation. CAFs and their soluble mediators provide multiple complex regulatory signals that modulate the trafficking, differentiation status, and function of inflammatory cells in the tumour microenvironment. This review focuses on pathways by which CAFs mediate tumour‐promoting inflammation and modify the components of the inflammatory microenvironment that facilitate tumour initiation, progression, and metastasis.Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.