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Epithelial–mesenchymal crosstalk alteration in kidney fibrosis
Author(s) -
Prunotto Marco,
Budd David C,
Gabbiani Giulio,
Meier Matthias,
Formentini Ivan,
Hartmann Guido,
Pomposiello Silvia,
Moll Solange
Publication year - 2012
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.4049
Subject(s) - crosstalk , mesenchymal stem cell , fibrosis , kidney disease , disease , medicine , kidney , pathological , bioinformatics , pathology , cancer research , biology , physics , optics
The incidence of chronic kidney diseases (CKD) is constantly rising, reaching epidemic proportions in the western world and leading to an enormous threat, even to modern health‐care systems, in industrialized countries. Therapies of CKD have greatly improved following the introduction of drugs targeting the renin–angiotensin system (RAAS) but even this refined pharmacological approach has failed to stop progression to end‐stage renal disease (ESRD) in many individuals. In vitro historical data and recent new findings have suggested that progression of renal fibrosis might occur as a result of an altered tubulo–interstitial microenvironment and, more specifically, as a result of an altered epithelial‐mesenchymal crosstalk. Here we the review biological findings that support the hypothesis of an altered cellular crosstalk in an injured local tubulo‐interstitial microenvironment leading to renal disease progression. Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.