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Cell–matrix interactions in muscle disease
Author(s) -
Carmignac Virginie,
Durbeej Madeleine
Publication year - 2012
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.3020
Subject(s) - dystroglycan , extracellular matrix , laminin , microbiology and biotechnology , muscular dystrophy , dystrophin , biology , integrin , myocyte , itga7 , cytoskeleton , cell , genetics
The extracellular matrix (ECM) provides a solid scaffold and signals to cells through ECM receptors. The cell–matrix interactions are crucial for normal biological processes and when disrupted they may lead to pathological processes. In particular, the biological importance of ECM–cell membrane–cytoskeleton interactions in skeletal muscle is accentuated by the number of inherited muscle diseases caused by mutations in proteins conferring these interactions. In this review we introduce laminins, collagens, dystroglycan, integrins, dystrophin and sarcoglycans. Mutations in corresponding genes cause various forms of muscular dystrophy. The muscle disorders are presented as well as advances toward the development of treatment. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.