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IL‐32 up‐regulation is associated with inflammatory cytokine production in allergic rhinitis
Author(s) -
Jeong HyunJa,
Shin SeungYoup,
Oh HyunA,
Kim MinHo,
Cho JoongSaeng,
Kim HyungMin
Publication year - 2011
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.2899
Subject(s) - cytokine , immunology , allergic inflammation , inflammation , mucous membrane of nose , medicine , granulocyte macrophage colony stimulating factor , immunoglobulin e , antibody
IL‐32 is a described pro‐inflammatory cytokine produced by T lymphocytes, natural killer cells, monocytes, and epithelial cells. However, the specific mechanism of IL‐32 on allergic rhinitis (AR) has not been elucidated. Here, we report a significant increase of IL‐32 protein and mRNA in the nasal mucosa of AR patients. In addition, in nasal mucosa tissue from AR patients, the level of IL‐32 production correlated with inflammation, IL‐1β, IL‐18, and granulocyte‐macrophage colony‐stimulating factor (GM‐CSF). In an AR animal model, IL‐32 significantly increased IgE and inflammatory cytokine levels. IL‐32 expression was induced by recombinant human GM‐CSF via activation of caspase‐1 in eosinophils. In addition, depletion of IL‐32 prevents the production of inflammatory cytokines in eosinophils. In conclusion, IL‐32 is an important cytokine involved in the inflammation of AR. The regulation of IL‐32 expression may form the basis of a new strategy for the treatment of AR. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.