Premium
Ski, a modulator of wound healing and scar formation in the rat skin and rabbit ear
Author(s) -
Li Ping,
Liu Ping,
Xiong RenPing,
Chen XingYun,
Zhao Yan,
Lu WeiPing,
Liu Xia,
Ning YaLei,
Yang Nan,
Zhou YuanGuo
Publication year - 2011
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.2831
Subject(s) - wound healing , scars , hypertrophic scar , granulation tissue , medicine , inflammation , fibroblast , pathology , microbiology and biotechnology , surgery , biology , immunology , cell culture , genetics
We recently demonstrated that Ski is a novel wound healing‐related factor that promotes fibroblast proliferation and inhibits collagen secretion. Here, we show that increasing local Ski expression by gene transfer not only significantly accelerated wound healing by relieving inflammation, accelerating re‐epithelialization and increasing formation of granulation tissue, but also reduced scar formation by decreasing collagen production in rat dermal wounds. Similarly, ski gene transfer accelerated wound healing, reduced the protuberant height and volume of scars and increased collagen maturity in a hypertrophic scar model in the rabbit ear. Conversely, reducing Ski expression in the wound by RNA interference resulted in significantly slower wound healing and increased scar area in rat dermal wounds. We demonstrated that these effects of Ski are associated with transforming growth factor‐β‐mediated signalling pathways through both Smad2/3‐dependent and Smad‐independent pathways. Together, our results define a dual role for Ski in promoting wound healing and alleviating scar formation, identifying a new target for therapeutic approaches to preventing scar hyperplasia and accelerating wound healing. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.