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Genetically informed lung cancer medicine
Author(s) -
Pao William,
Iafrate A John,
Su Zengliu
Publication year - 2011
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.2788
Subject(s) - lung cancer , medicine , prioritization , cancer , intensive care medicine , precision medicine , bioinformatics , oncology , pathology , biology , management science , economics
Abstract Knowledge of tumour mutation status has become increasingly important for the prioritization of targeted therapies for cancer. We review here the major known ‘driver’ mutations with therapeutic relevance in non‐small cell lung cancer. We also discuss a variety of methods now being employed in molecular diagnostic laboratories to detect genetic alterations in lung tumours. A genetically‐informed approach to lung cancer medicine is rapidly becoming the standard of care worldwide and should lead to improved outcomes for patients. Copyright © 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.