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Regulation of tissue‐ and stimulus‐specific cell fate decisions by p53 in vivo
Author(s) -
Jackson James G,
Post Sean M,
Lozano Guillermina
Publication year - 2011
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.2783
Subject(s) - cell fate determination , biology , suppressor , dna damage , microbiology and biotechnology , cell , senescence , programmed cell death , cell growth , cancer research , cell cycle checkpoint , cell cycle , dna , genetics , transcription factor , apoptosis , cancer , gene
Abstract The tumour suppressor p53 pathway is often inactivated by multiple mechanisms in the genesis of human cancers. Aberrant cellular proliferation, DNA damage, hypoxia, and ribosomal stress cause activation of the p53 tumour suppressor with multiple possible consequences to the cell: cell death, cell cycle arrest, or senescence. These mechanisms ultimately ensure that the cell does not replicate, and are thus potent tumour suppressor mechanisms. An important question that has eluded the field is how p53 makes these cell fate decisions. This review summarizes the current status of knowledge regarding p53 ‐mediated stress and tissue‐dependent cell fate decisions in mouse models and human tumours. Copyright © 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.