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Anaplastic plasmacytomas: relationships to normal memory B cells and plasma cell neoplasms of immunodeficient and autoimmune mice
Author(s) -
Qi ChenFeng,
Shin DongMi,
Li Zhaoyang,
Wang Hongsheng,
Feng Jianxum,
Hartley Janet W,
Fredrickson Torgny N,
Kovalchuk Alexander L,
Morse Herbert C
Publication year - 2010
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.2692
Subject(s) - plasma cell , germinal center , biology , plasmacytoma , microbiology and biotechnology , congenic , flow cytometry , phenotype , immunofluorescence , pathology , antibody , b cell , gene , immunology , genetics , medicine , multiple myeloma
Anaplastic plasmacytomas (APCTs) from NFS.V + congenic mice and pristane‐induced plasmacytic PCTs from BALB/c mice were previously shown to be histologically and molecularly distinct subsets of plasma cell neoplasms (PCNs). Here we extended these comparisons, contrasting primary APCTs and PCTs by gene expression profiling in relation to the expression profiles of normal naïve, germinal centre, and memory B cells and plasma cells. We also sequenced immunoglobulin genes from APCT and APCT‐derived cell lines and defined surface phenotypes and chromosomal features of the cell lines by flow cytometry and by spectral karyotyping and fluorescence in situ hybridization. The results indicate that APCTs share many features with normal memory cells and the plasma cell‐related neoplasms (PLs) of FASL‐deficient mice, suggesting that APCTs and PLs are related and that both derive from memory B cells. Published in 2010 by John Wiley & Sons, Ltd.