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p53 transcriptional pathways in breast cancer: the good, the bad and the complex
Author(s) -
Thompson Alastair M,
Lane David P
Publication year - 2010
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.2674
Subject(s) - breast cancer , malignancy , context (archaeology) , mdm2 , pathological , cancer , medicine , oncology , bioinformatics , biology , gene , genetics , paleontology
A p53 network immunohistochemically‐based signature to discriminate between good and poor prognosis breast cancer would have clinical relevance, given the key role of p53 in malignancy and response to therapy. Utilizing a five‐protein signature of p53/mdm2/mdm4/bcl2/p21 discriminates good‐prognosis and poor‐prognosis patient groups, based on the functionality of the p53 network. However, the relationship of this five‐protein signature to p53 mutation, the wide range of breast cancer therapies now in use and the over‐70 age group remain uncertain. Nonetheless, confirmation of the signature in two independent series suggests that this approach should be considered in further case series and in the context of clinical trials. Copyright © 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.