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Does massively parallel DNA resequencing signify the end of histopathology as we know it?
Author(s) -
Aparicio Samuel AJR,
Huntsman David G
Publication year - 2010
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.2636
Subject(s) - massive parallel sequencing , dna sequencing , genome , genomics , biology , computational biology , cancer , personal genomics , genetics , dna , gene
Next‐generation DNA sequencing devices have revolutionized cancer genomics by bringing whole genome resequencing of patients' tumours within practical and economic reach. We present an overview of the techniques involved and review early results from the resequencing of cancer genomes. The possible impacts of whole‐genome and trancriptome resequencing in clinical cancer research and the practice of pathology are discussed. Copyright © 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.