Premium
Activated macrophages in the tumour microenvironment—dancing to the tune of TLR and NF‐κB
Author(s) -
Hallam Simon,
EscorcioCorreia Monica,
Soper Robin,
Schultheiss Anne,
Hagemann Thorsten
Publication year - 2009
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.2602
Subject(s) - macrophage , phenotype , tumor microenvironment , population , biology , nf κb , immunology , pathological , microbiology and biotechnology , cancer research , medicine , pathology , tumor cells , inflammation , in vitro , genetics , environmental health , gene
Abstract A large number of variables have been identified which appear to influence macrophage phenotype within the tumour microenvironment. These include reciprocal chemical and physical interactions with tumour cells and with non‐malignant cells of the tumour microenvironment, tissue oxygen tension, and the origin and prior experience of the particular macrophage population. In this review we outline the key evidence for these influences and consider how macrophage phenotype is acquired and the relevance of the TLR–NF‐κB pathway. Copyright © 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.