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Insulin receptor activation in solitary fibrous tumours
Author(s) -
Li Y,
Chang Q,
Rubin BP,
Fletcher CDM,
Morgan TW,
Mentzer SJ,
Sugarbaker DJ,
Fletcher JA,
Xiao S
Publication year - 2007
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.2136
Subject(s) - autocrine signalling , receptor , gene isoform , insulin like growth factor , growth factor , insulin receptor , biology , cancer research , insulin , endocrinology , medicine , microbiology and biotechnology , insulin resistance , gene , biochemistry
Solitary fibrous tumours (SFTs) are known to overexpress insulin‐like growth factor 2 (IGF‐2). The down‐stream oncogenic pathways of IGF‐2, however, are not clear. Here we report uniform activation of the insulin receptor (IR) pathway in SFTs, which are mesenchymal tumours frequently associated with hypoglycaemia. Whereas the IR and its downstream signalling pathways were constitutively activated in SFTs, insulin‐like growth factor 1 receptor (IGF‐1R) was not expressed in these tumours. We also find that SFT cells secrete IGF‐2 and proliferate in serum‐free medium, consistent with an IGF‐2/IR autocrine loop. The aetiological relevance of IGF‐2 is supported by expression of IR‐A, the IR isoform with high affinity for IGF‐2, in all SFTs. Our studies suggest that IR activation plays an oncogenic role in SFTs. Copyright © 2007 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.