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New insights into the function of granulomas in human tuberculosis
Author(s) -
Ulrichs Timo,
Kaufmann Stefan HE
Publication year - 2006
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1906
Subject(s) - tuberculosis , mycobacterium tuberculosis , granuloma , immune system , human lung , immunology , lung function , function (biology) , medicine , granuloma formation , biology , pathology , lung , evolutionary biology
The human tuberculous granuloma provides the morphological framework for local immune processes central to the outcome of tuberculosis. This review article describes investigations on human lung granulomas aimed at better understanding the regional host response and counter‐measures to Mycobacterium tuberculosis . These findings lead to a revised view of the regional immune response in human tuberculosis. Novel insights into this dynamic cross‐talk form the basis of novel intervention strategies. Copyright © 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.