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Aberrant expression of TTF‐1 and forkhead factor HFH‐4 in atrophic gastritis and ciliated metaplasia suggests gastric broncho‐pulmonary transdetermination
Author(s) -
Rau Tilman,
Dimmler Arno,
Häfner Manuela,
Brabletz Thomas,
Kirchner Thomas,
Faller Gerhard
Publication year - 2005
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1795
Subject(s) - atrophic gastritis , gastric mucosa , intestinal metaplasia , immunohistochemistry , metaplasia , pathology , stomach , pathological , cancer , medicine , gastritis , biology
Ciliated metaplasia (CM) in the stomach is mainly found in gastric mucosa that harbours gastric cancer. The true nature of this lesion and the regulatory factors responsible for the formation of CM are unknown. Broncho‐pulmonary differentiation is controlled by the homeodomain transcription factor TTF‐1 and ciliogenesis by the forkhead transcription factor HFH‐4, respectively. Using immunohistochemistry, the present study shows that gastric CM is associated with the expression of TTF‐1 and HFH‐4. Furthermore, TTF‐1 expression was found in non‐ciliated cells in 50% of cases with atrophic gastritis, whereas TTF‐1 and HFH‐4 were not expressed in normal gastric mucosa or in non‐atrophic gastritis. These data suggest that CM in the gastric mucosa can be regarded as gastric broncho‐pulmonary transdetermination. Evidence for this particular transdetermination is frequently found in atrophic gastritis even without fully developed ciliated cells. Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.