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CDX2 co‐localizes with liver–intestine cadherin in intestinal metaplasia and adenocarcinoma of the stomach
Author(s) -
Ko Samuel,
Chu KentMan,
Luk John MoonChing,
Wong Bonnie WingYan,
Yuen SiuTsan,
Leung SuetYi,
Wong John
Publication year - 2005
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1741
Subject(s) - cdx2 , intestinal metaplasia , cadherin , immunohistochemistry , adenocarcinoma , stomach , cancer , gastric mucosa , small intestine , biology , cancer research , pathology , medicine , gene expression , gene , biochemistry , genetics , cell , homeobox
CDX2 and liver–intestine (LI)‐cadherin are intestine‐specific markers and both are physiologically expressed in the small intestine and colon. Recent studies have demonstrated that CDX2 regulates LI‐cadherin gene ( CDH17 ) expression in colorectal cancer. The present study investigated the relationship of CDX2 and LI‐cadherin expression in gastric cancer. One hundred and nine pairs of tumour and non‐cancerous gastric mucosa were collected from gastrectomy specimens. Protein expression levels of CDX2 and LI‐cadherin were determined by immunohistochemical staining. Semi‐quantitative RT‐PCR showed that the mRNAs of both CDX2 and CDH17 were highly expressed in tumour compared with non‐cancerous mucosa. Overexpression of CDX2 was significantly associated with CDH17 in gastric adenocarcinoma. Furthermore, the expression of CDX2 and LI‐cadherin proteins was strongly coupled in intestinal metaplasia. In conclusion, overexpression of CDH17 is significantly associated with CDX2 . Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.