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Simultaneous over‐expression of the Her2/neu and PTK6 tyrosine kinases in archival invasive ductal breast carcinomas
Author(s) -
Born Martina,
QuintanillaFend Leticia,
Braselmann Herbert,
Reich Uli,
Richter Manfred,
Hutzler Peter,
Aubele Michaela
Publication year - 2005
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1720
Subject(s) - oncogene , tyrosine kinase , biology , gene , kinase , cancer research , receptor tyrosine kinase , gene expression , her2/neu , chromosome , pathology , breast cancer , medicine , cancer , signal transduction , genetics , cell cycle
Expression of eight tumour‐relevant genes was studied in formalin‐fixed, paraffin‐embedded tissue from 54 invasive ductal breast carcinomas using quantitative reverse transcription PCR (Q‐RT‐PCR). Seven of the genes map to chromosome 20q and are potential candidates for gene amplification and over‐expression. The Her2/neu oncogene, on chromosome 17q, was investigated in the same tumours. Increased expression was most frequent for PTK6, Her2/neu , and ADA . No other 20q candidate gene ( AIB1, PTPN1, ZNF217 , and PFDN4 ) was prominent. A significant correlation between the expression of the tyrosine kinases PTK6 and Her2/neu was detected. The frequent elevation of PTK6 expression (in 43/54 tumours), and its correlation with Her2/neu oncogene over‐expression, suggests a clinically relevant link between these two over‐expressed tyrosine kinases. Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.