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Expression of basic fibroblast growth factor and fibroblast growth factor receptor in advanced gastric carcinoma
Author(s) -
Ueki Takashi,
Koji Takehiko,
Tamiya Sadafumi,
Nakane Paul K.,
Tsuneyoshi Masazumi
Publication year - 1995
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711770405
Subject(s) - fibroblast growth factor receptor 3 , fibroblast growth factor receptor 2 , fibroblast growth factor receptor 4 , fibroblast growth factor receptor , cancer research , fibroblast growth factor , growth factor receptor inhibitor , fibroblast growth factor receptor 1 , fibroblast , fibroblast growth factor 23 , receptor , fgf1 , basic fibroblast growth factor , growth factor , biology , microbiology and biotechnology , chemistry , medicine , genetics , cell culture , parathyroid hormone , calcium
The expression of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor (FGFR) mRNA was examined in gastric carcinomas by immunohistochemistry and in situ hybridization, respectively. In the 20 advanced carcinomas examined, bFGF was found in 14 (70·0 per cent) and was confined to the tumour cells, whereas FGFR mRNA was demonstrated in 12 (60·0 per cent) and seen in both tumour cells and endothelial cells. The bFGF and FGFR mRNA‐positive carcinomas were larger, were more frequently classified as undifferentiated adenocarcinoma, more frequently invaded the serosal layer, and had a higher rate of lymph node metastases than the bFGF and FGFR mRNA‐negative carcinomas. Patients with bFGF and FGFR mRNA‐positive carcinomas appear to die earlier than those with bFGF and FGFR mRNA‐negative tumours. The values for the carcinomas that were positive for either bFGF or FGFR mRNA fell between these two groups. The findings suggest that the autocrine/paracrine bFGF/FGFR channel is associated with undifferentiated gastric carcinomas and may lead to a poorer prognosis.