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An infarct‐like myocardial lesion experimentally induced in wistar rats with Africanized bee venom
Author(s) -
Ferreira Dirceu B.,
Costa Roberto S.,
De Oliveira J. A. Mello,
Muccillo Gerson
Publication year - 1995
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711770114
Subject(s) - necrosis , lesion , venom , myocardial infarction , enzyme , inoculation , pathology , bee venom , medicine , biology , biochemistry , zoology
Abstract There is evidence in the literature that death following a bee or wasp sting may result from cardiac involvement. This study describes acute cardiac lesions experimentally induced in Wistar rats submitted to intravenous inoculation of Africanized bee venom (ABV) and killed 1, 4, and 24 h after inoculation. Significant increases in serum enzyme levels were detected; light microscopy showed necrosis of the myocardium; and enzyme histochemistry showed inactivation of enzymes in and around the areas of necrosis. This is the first report of an acute necrotizing cardiac lesion, similar to human myocardial infarction, produced by the inoculation of ABV.