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ICAM‐1 and VCAM‐1 expression in accelerated cardiac allograft arteriopathy and myocardial rejection are influenced differently by cyclosporine a and tumour necrosis factor‐α blockade
Author(s) -
Molossi Silvana,
Clausell Nadine,
Sett Suvro,
Rabinovitch Marlene
Publication year - 1995
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711760211
Subject(s) - immunostaining , vcam 1 , cell adhesion molecule , coronary arteries , transplantation , intercellular adhesion molecule 1 , medicine , heart transplantation , necrosis , pathology , tumor necrosis factor alpha , icam 1 , myocyte , immunohistochemistry , immunology , artery
Expression of the vascular cell adhesion molecules intercellular adhesion molecule‐1 (ICAM‐1) and vascular cell adhesion molecule‐1 (VCAM‐1) occurs in allograft myocardium and in coronary arteries, promoting adhesion and transendothelial migration of inflammatory cells. We therefore investigated, in cholesterol‐fed rabbits 9–10 days following heterotopic cardiac transplantation, whether the reduction of both myocardial rejection and graft arteriopathy with cyclosporine A (CsA) or graft arteriopathy alone with tumour necrosis factor‐α soluble receptor (TNFsr) was associated with suppression of ICAM‐1 and VCAM‐1 expression. Host hearts showed negative immunostaining for these adhesion molecules, whereas donor specimens from untreated (control) rabbits showed moderate immunostaining for ICAM‐1 and weaker immunostaining for VCAM‐1 in the coronary arteries, myocardium (cardiac myocytes), and perivenular regions. The selective reduction of the coronary arteriopathy with TNFsr was associated with somewhat reduced expression of these adhesion molecules in the arteries, whereas CsA also suppressed myocardial rejection and markedly decreased both vascular and myocyte expression of ICAM‐1 and VCAM‐1.