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An evaluation of the cell cycle‐associated monoclonal antibody Ki‐S1 as a prognostic factor in primary invasive adenocarcinoma of the breast
Author(s) -
Morris E. S.,
Elston C. W.,
Bell J. A.,
Galea M.,
Blamey R. W.,
Ellis I. O.
Publication year - 1995
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711760109
Subject(s) - immunohistochemistry , monoclonal antibody , antigen , breast carcinoma , adenocarcinoma , pathology , carcinoma , ki 67 , antibody , mitosis , medicine , biology , oncology , breast cancer , cancer , immunology , microbiology and biotechnology
Immunohistochemical staining with the novel monoclonal antibody Ki‐S1, believed to recognize a cell cycle‐associated antigen, was investigated in 110 cases of invasive carcinoma of the breast. Immunoreactivity indices were compared with disease‐free interval (DFI), overall survival, and a series of other prognostic indicators. Significant positive correlations were found between the percentage of strongly positive immunoreactive nuclei and tumour size, histological grade and type, vascular invasion, and mitotic count. A significant negative correlation was found with age. No significant correlation was found with either DFI or overall survival. Although a correlation with mitotic count does imply that the Ki‐S1 antigen is cell cycle‐associated to some extent, Ki‐S1 does not appear to be a useful prognostic factor in human breast carcinoma.