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Mononuclear cell thyroiditis in rats with graft‐versus‐host disease
Author(s) -
Fujiwara Kouji,
Peszkowski Michael J.,
Larsson Åke,
Yamasaki Akira,
Toda Shuji,
Watanabe Teruo
Publication year - 1995
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711750313
Subject(s) - mononuclear cell infiltration , thyroid , cytotoxic t cell , peripheral blood mononuclear cell , spleen , thyroiditis , cd8 , infiltration (hvac) , pathology , graft versus host disease , effector , lesion , medicine , immunology , biology , immune system , disease , endocrinology , in vitro , biochemistry , physics , thermodynamics
Rats with graft‐versus‐host disease (GVHD), induced by injecting spleen cells of parental strain rats (Brown Norway) into non‐irradiated (Brown Norway × Lewis) F1 hybrid rats, develop thyroiditis. This is characterized by mononuclear cell infiltration with destruction of the epithelium and a significant reduction in serum thyroid hormone levels. Immunohistochemically, the mononuclear cells consisted mainly of CD8‐positive cells and macrophages. These findings provide evidence that the thyroid gland can now be enumerated as one of the target organs during GVHD. The CD8‐positive cells may serve as important effector cells in lesion development, either by direct cytotoxicity or by supporting the cytotoxic potential of macrophages.