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Expression of c‐myc protein is related to cell proliferation and expression of growth factor receptors in transitional cell bladder cancer
Author(s) -
Lipponen Pertti K.
Publication year - 1995
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711750208
Subject(s) - bladder cancer , cytoplasm , biology , immunohistochemistry , receptor , mitotic index , cancer research , epidermal growth factor receptor , pathology , cancer , medicine , mitosis , microbiology and biotechnology
Archival biopsy specimens from transitional cell bladder tumours ( n =185) were analysed immunohistochemically for expression of c‐ myc protein. The results were compared with compared with histopathological and clinical parameters and survival. Forty‐three per cent of the tumours were negative for c‐ myc protein and weak, moderate, or strong cytoplasmic expression was found in 34, 14, and 9 per cent of cases, respectively. Nuclear positivity for c‐ myc protein was detected in 35 per cent of tumours and nuclear opositivity was related to overexpression of c‐erb B‐2 ( P =0.01) and a high proportion of nuclei were also positive for p53 oncoprotein ( p <0.05). Cytoplasmic expression of c‐ myc protein was related to histological grade ( P =0.005), papillary status ( P =0.007), the S‐phase fraction ( P =0.008), the mitotic index ( P =0.021), overexpression of epidermal growth factor receptor ( P =0.045), and c‐erb B‐2 ( P =0.17). Expression of c‐ myc protein was not significantly related to the progression of tumours and it had no prognostic value in survival analysis. Independent predictors were the T‐category ( P <0.001), papillary status. (P=0.001), and S‐phase fraction ( P =0.061). The results show that while c‐ myc gene product participates in growth regulation of human bladder cancer cells, it has no independent prognostic significance.