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Development of papillary renal cell tumours is associated with loss of Y‐chromosome‐specific DNA sequences
Author(s) -
Kovacs Gyula,
Tory Kalman,
Kovacs Angela
Publication year - 1994
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711730107
Subject(s) - loss of heterozygosity , chromosome , biology , papillary renal cell carcinomas , homologous chromosome , pathology , chromosome 17 (human) , y chromosome , kidney , chromosome 3 , chromosome 9 , cancer research , microbiology and biotechnology , allele , genetics , gene , medicine
Twenty‐two papillary renal cell tumours were analysed by Southern hybridization using eight DNA probes from homologous regions of the X and Y chromosomes and two Y‐chromosome‐specific DNA probes. Sixteen of the 19 papillary renal cell tumours of male patients showed the loss of Y‐chromosome‐specific sequences. No loss of heterozygosity was detected in three tumours that developed in females. The frequency of loss of the Y chromosome was established in 50 non‐papillary renal cell carcinomas as well. Only seven of the 31 non‐papillary renal cell carcinomas obtained from male patients had lost the Y‐chromosome‐specific sequences, whereas no allelic loss was found in 19 non‐papillary tumours obtained from female patients. Papillary renal cell tumours show a strong male preponderance (6:1) and loss of Y chromosome in 84 per cent of the cases, whereas non‐papillary renal cell carcinomas show only a slight male preponderance (1:5:1) and the Y chromosome is lost in only 22 per cent of the cases. These data suggest that a tumour suppressor gene is localized at one of the homologous regions of the X and Y chromosomes, the homozygous inactivation of which is associated with the development of papillary renal cell tumours.