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Co‐expression of endothelial cell and macrophage antigens in Kaposi's sarcoma cells
Author(s) -
Uccini Stefania,
Ruco Luigi P.,
Monardo Francesca,
Stoppacciaro Antonella,
Dejana Elisabetta,
La Parola Ilaria Lesi,
Cerimele Decio,
Baroni Carlo D.
Publication year - 1994
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711730105
Subject(s) - vitronectin , cd68 , cd31 , cell adhesion molecule , antigen , pathology , immunocytochemistry , endothelial stem cell , macrophage , von willebrand factor , biology , immunology , immunohistochemistry , medicine , integrin , cell , platelet , biochemistry , genetics , in vitro
The histopathogenesis of Kaposi's sarcoma (KS) was investigated using immunocytochemistry in 12 skin biopsies obtained from two AIDS patients, nine patients with the classic form, and one organ‐transplant patient. KS cells revealed a peculiar antigenic profile, being characterized by co‐expression of endothelial and macrophage markers. KS cells were stained for von Willebrand factor (vWF); for vascular endothelial (VE) cadherin, an endothelial specific adhesion molecule; and for PECAM/CD31. In addition, they expressed the macrophage antigens PAM‐1, CD68, and CD14, and were positive for vitronectin receptor and alpha‐1,5,6/beta‐1 integrins. KS cells were weakly stained for ICAM‐1 in 6 of 12 cases and were negative for VCAM‐1 and E‐selectin.