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Electron microscopic study of the attachment and penetration of rabbit intestinal epithelium by Providencia alcalifaciens
Author(s) -
Mathan Minnie M.,
Mathan Vadakenadayil I.,
Albert M. John
Publication year - 1993
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711710114
Subject(s) - endocytosis , penetration (warfare) , enterocyte , microbiology and biotechnology , intracellular , electron microscope , tight junction , transmission electron microscopy , epithelium , biology , chemistry , cell , nanotechnology , materials science , biochemistry , small intestine , physics , genetics , optics , operations research , engineering
Ilea of adult rabbits with removable ileal ties (RITARD model) that developed diarrhoea and ileal loops of adult rabbits after inoculation with Providencia alcalifaciens , isolated from two patients with diarrhoea, were studied by transmission electron microscopy for enterocyte‐bacterial interactions. Two modes of entry of bacteria into epithelial cells were seen: one directly by endocytosis associated with polymerization of cytoskeletal components and the other by disruption of tight junctions with entry into and proliferation in intercellular spaces.