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Three‐dimensional reconstruction of human embryonic notochords: Clue to the pathogenesis of chordoma
Author(s) -
Salisbury Jonathan R.,
Deverell Mark H.,
Cookson M. John,
Whimster William F.
Publication year - 1993
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711710112
Subject(s) - notochord , histogenesis , anatomy , chordoma , biology , embryo , embryogenesis , pathology , microbiology and biotechnology , medicine , immunohistochemistry , immunology
Abstract Three‐dimensional reconstruction experiments performed on serial sections of human embryos showed that the anatomy of the caudal and rostral ends of the notochord was complex. Forking of the ends, with separate fragments of chordal tissue, was demonstrated and these provide a way by which notochordal cell rests could be left behind in the basicranial and sacral regions when the notochord involutes elsewhere. Assuming the histogenesis of chordomas from notochordal cell rests, this would furnish an explanation for the observed skeletal distribution of chordomas.