Premium
Expression of proliferating cell nuclear antigen (PCNA) in dysplasia of the bronchial epithelium
Author(s) -
Pendleton Neil,
Dixon Glen R.,
Burnett Heather E.,
Occleston Nicholas L.,
Myskow Michael W.,
Green John A.
Publication year - 1993
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711700212
Subject(s) - proliferating cell nuclear antigen , dysplasia , pathology , epithelium , immunohistochemistry , biology , mitosis , antigen , cell growth , proliferation marker , medicine , immunology , microbiology and biotechnology , genetics
Abstract Proliferating cell nuclear antigen (PCNA) is expressed in cells in the cell cycle and has been studied as a marker of proliferation in lung and other tumours. We have noted immunocytochemical differences in PCNA expression between normal and neoplastic bronchial cells. As bronchial dysplasia is considered preneoplastic, we have examined PCNA expression in this condition. PCNA staining in 47 cases of bronchial dysplasia and 32 samples of normal bronchial epithelium was compared. Of the dysplasias, three were mild, 11 moderate, and 33 severe. A significant increase in PCNA counts over normal epithelium was seen only in moderate and severe dysplasias. In dysplasia, mitotic indices showed a significant positive correlation with the percentage of PCNA‐positive cells. We conclude that in moderate and severe dysplasias there is an increase in the number of cells expressing PCNA and undergoing division, indicating abnormal growth control.