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BCL ‐2 expression in adult and embryonic non‐haematopoietic tissues
Author(s) -
Lu QiLong,
Poulsom Richard,
Wong Leslie,
Hanby Andrew M.
Publication year - 1993
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711690408
Subject(s) - biology , embryonic stem cell , haematopoiesis , stem cell , cellular differentiation , microbiology and biotechnology , pathology , gene , medicine , biochemistry
The B‐cell leukaemia/lymphoma‐2 ( bcl‐2 ) proto‐oncogene is unusual as its product appears to provide survival advantage to B cells by blocking apoptosis. In this study, the expression of bcl‐2 has been examined in normal nonhaematopoietic tissues, embryos, and psoriatic skin by immunohistochemical staining. Bcl‐ 2 protein expression is mainly observed in cell populations with a long life and/or proliferating ability such as duct cells in exocrine glands, basal keratinocytes, cells at the bottom of colon crypts, and neurons. In the skin of both adult and embryo and also embryonic kidney and cartilage, bcl‐ 2 expression was observed in cells which were undergoing morphological transition from undifferentiated stem cells to committed precursor cells. The finding of bcl‐ 2 expression in the terminal differentiated syncytial trophoblast, but not cytotrophoblast, and in some cells responsive to hormone stimulation such as in the endometrium and myometrium suggests that the gene expression may be related too hormone responsiveness. As no bci‐ 2 localization was seen in the benign hyperproliferative skin condition psoriasis, this does not suggest a straightforward link to proliferation. These observations support the view that the bcl‐ 2 gene may have an important role in cell development, maturation, and the path to terminal differentiation.