Premium
Gene rearrangement of bcl‐1 and bcl‐2 is confined to distinct subgroups of high‐grade malignant B‐cell lymphomas
Author(s) -
Ott M. Michaela,
Dahlheimer Kathrin,
MüllerHermelink Hans K.,
Feller Alfred C.
Publication year - 1993
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711690305
Subject(s) - lymphoma , gene rearrangement , follicular lymphoma , pathology , cancer research , gene , biology , medicine , genetics
The occurrence of bcl‐1 and bcl‐2 gene rearrangements was investigated in 37 cases of high‐grade B‐cell lymphomas. Bcl‐2 rearrangement was detectable only in single cases of primary centroblastic lymphoma with a follicular growth pattern, whereas secondary centroblastic lymphomas evolving from a centroblastic–centrocytic lymphoma were positive in up to 60 per cent of the cases analysed. Bcl‐1 rearrangement was found only in one case of immunoblastic B‐cell lymphoma with a history of a pre‐existing lymphoplasmacytoid immunocytoma. It is concluded that there may be a subgroup of centroblastic lymphomas with a biology similar to that of centroblastic–centrocytic lymphomas. The detection of bcl‐1 rearrangement in high‐grade lymphomas may indicate a secondary high‐grade lymphoma.