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Proliferation and differentiation of tumour cells from B‐cell lymphoma of mucosa‐associated lymphoid tissue in vitro
Author(s) -
Hussell Tracy,
Isaacson Peter G.,
Spencer Jo
Publication year - 1993
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711690208
Subject(s) - lymphoma , immune system , antigen , immunology , idiotype , b cell , biology , mucosa associated lymphoid tissue , antibody , lymphokine , cancer research , malt lymphoma , pathology , monoclonal antibody , medicine
Several characteristics of lymphomas of mucosa‐associated lymphoid tissue (MALT type) suggest that they are antigen‐dependent and that their growth parodies a normal immune response. We have previously shown that three cases of low‐grade B‐cell MALT‐type lymphoma recognize autoantigens. In this study, we investigated the response of three low‐grade and one high‐grade case of MALT‐type lymphoma to anti‐idiotypic antibody as a model of antigen binding either alone or as a co‐stimulus with B‐cell mitogens. We also studied the response of tumour cells to interleukin‐6 (IL‐6), which induces differentiation to immunoglobulin‐producing cells in many systems. Of the four cases studied, one low‐grade case showed markedly enhanced proliferation in response to anti‐idiotype alone. This could not be increased by the addition of mitogens. In the remaining two low‐grade cases, mitogen responsiveness was observed which was affected by anti‐idiotype either by an enhancement or by a reduction in the proliferative response. The high‐grade case failed to respond to the stimuli studied. No response to IL‐6 was observed. This study supports the suggestion that antigen may affect the pathogenesis of low‐grade tumours of MALT type.