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Effect of cholesterol on the position of segmental lesions in unilaterally nephrectomized rats
Author(s) -
Green Nicholas J.,
Howie Alexander J.,
Rayner Hugh C.,
Walls John
Publication year - 1992
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711680314
Subject(s) - nephrectomy , cholesterol , medicine , kidney , hilum (anatomy) , endocrinology , cholic acid , lesion , pathology , surgery
Different positions of segmental lesions within glomeruli may correspond to different pathogenetic mechanisms. The effect of a high cholesterol diet on the position of lesions had not previously been investigated. This was studied in rats following unilateral nephrectomy, as a change in position would suggest a different mechanism of damage. Thirty‐two female WAG/ola rats had unilateral nephrectomy. Half the rats were given a diet supplemented with 4 per cent cholesterol and 1 per cent cholic acid. At death, six at 10 weeks after nephrectomy and the rest at 24 weeks, kidney sections were examined microscopically. There were significantly more segmental lesions in the cholesterol‐fed rats than in the controls, and these lesions were almost entirely at the glomemerular hilum in both groups. Significantly more glomeruli contained foamy cells in the cholesterol‐fed group, both within lesions and away from them. These findings confirmed that in reduced renal mass, segmental lesions are mainly hilar. The diet increases the number of glomeruli affected by lesions, but these are still mainly hilar. Therefore one possibility is that hypercholesterolaemia worsens the hyperfiltration effect on glomeruli. The diet also produces foamy cells scattered throughout the glomeruli but these do not appear to develop into segmental lesions.