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Epidermotropism of T cells correlates with intercellular adhesion molecule (ICAMI) expression in human papillomavirus (HPV)‐induced lesions
Author(s) -
Viac J.,
Chardonnet Y.,
Euvrard S.,
Schmitt D.
Publication year - 1992
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711680310
Subject(s) - antigen , epidermis (zoology) , immune system , intercellular adhesion molecule 1 , biology , keratinocyte , pathology , immunohistochemistry , cd8 , lymphocyte , cell adhesion molecule , immunology , microbiology and biotechnology , medicine , cell culture , anatomy , genetics
Adhesion molecules play an important role in inflammatory reactions. Among them, ICAM1, a ligand for the lymphocyte function‐associated antigen (FLA1) of leucocytes, may be expressed by antigen‐presenting cells and keratinocytes in various inflammatory disorders. As cell‐mediated immune responses play a great role in HPV infections, we investigated the expression of ICAM1 and correlated it with the presence of LFA1‐positive cells by immunohistochemistry on serial frozen sections of a series of non‐regressing cutaneous and mucosal HPV‐induced lesions. ICAM1 expression by keratinocytes was observed only in intensely infiltrated lesions of condylomas and laryngeal papillomas. Its induction was usually correlated with the presence of LFA1‐positive cells (mainly CD8‐positive cells) which were in close apposition to ICAM1‐positive proliferative epithelial cells expressing also, in some cases, HLA‐DR antigen. ICAM1 was not correlated with the presence of HPV DNA or viral antigen. In moderately infiltrated lesions, keratinocytes did not express ICAM1, and LFA1 ‐positive cells were not observed in the epidermis. In all lesions, ICAM1 was more intense on endothelial cells than in normal skin; infiltrating cells (lymphocytes and dendritic cells) may also express this antigen but intraepithelial Langerhans cells were devoid of anylabelling. These studies provide further evidence that T‐lymphocyte mechanisms are important in the host response to HPV‐induced lesions. ICAM1 expression correlates with a lesional infiltrate but not with HPV infection and probably results in a more efficient initiation of the immune reaction.