Premium
The erbB‐3 Gene in human pancreatic cancer
Author(s) -
Lemoine Nicholas R.,
Lobresco Maria,
Leung Hing,
Barton Claire,
Hughes Christine M.,
Prigent Sally A.,
Gullick William J.,
Klöppel Günter
Publication year - 1992
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711680305
Subject(s) - autocrine signalling , pancreatic cancer , pancreas , cancer research , biology , epidermal growth factor receptor , erbb , epidermal growth factor , cancer , receptor , pancreatitis , pathogenesis , southern blot , gene , medicine , endocrinology , genetics , immunology
Abnormalities of the type 1 growth factor receptor family have been implicated in the pathogenesis of pancreatic cancer. There is evidence for a potential autocrine loop involving overexpression of the epidermal growth factor (EGF) receptor and its ligands, as well as overexpression of the erbB‐ 2 receptor. A third member of this receptor family, erbB‐ 3, has recently been recognized and found to be abnormally expressed in some types of human cancer. In this study we show that overexpression of the erbB‐ 3 protein occurs very frequently in carcinoma of the exocrine pancreas and also in chronic pancreatitis. We found no evidence of amplification or rearrangement of the erbB‐ 3 gene by Southern blot analysis of DNA from pancreatic cancer cells lines.