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Aberrant expression of the tumour suppressor gene p53 is very frequent in Wilms' tumours
Author(s) -
Lemoine Nicholas R.,
Hughes Christine M.,
Cowell John K.
Publication year - 1992
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711680213
Subject(s) - wilms tumour , suppressor , wilms' tumor , cancer research , tumor suppressor gene , gene , biology , genetics , carcinogenesis
A series of 34 Wilms' tumours have been analysed for abnormal expression of the tumour suppressor gene p53 using frozen section immunohistochemistry. All tumours showed immunoreactivity with at least one of the specific antibodies used (monoclonal antibody PAb240, polyclonal antibodies CM 1 and JG8). Abnormalities of p53 expression are very frequent in this type of childhood tumour.