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Distribution and localization of Epstein–Barr virus subtypes A and B in AIDS‐related lymphomas and lymphatic tissue of HIV‐positive patients
Author(s) -
Borisch B.,
Finke J.,
Hennig I.,
Delacréataz F.,
Schneider J.,
Heitz Ph. U.,
Laissue J. A.
Publication year - 1992
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711680212
Subject(s) - lymphoma , lymphatic system , epstein–barr virus , virus , pathology , in situ hybridization , immunohistochemistry , pathogenesis , lymphoproliferative disorders , gammaherpesvirinae , herpesviridae , biology , virology , viral disease , medicine , gene , messenger rna , biochemistry
Tissue samples of 421 HIV‐positive patients have been studied for the presence and distribution of Epstein–Barr virus (EBV) subtypes A and B. This was done by PCR, EBER in situ hybridization, and immunohistochemical detection of EBV latent membrane protein (LMP) in AIDS‐associated malignant lymphomas (16 cases) and lymphatic organs of patients without lymphoma (5 cases). Eleven cases were considered to be EBV‐positive, with type A in four, and type B virus in four other cases. In patients with malignant lymphoma, EBV was localized in tumour tissue exclusively. One patient without lymphoma presented with multiple EBV genome type B‐positive cells in all the lymphoid tissue samples examined. In HIV‐positive patients, both subtypes of EBV, A and B, may play a role in the pathogenesis of lymphoproliferative lesions.